Drug interactions
Olodaterol inhaled + Trimipramine
Severity: Moderate
Olodaterol inhaled and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants can potentiate the cardiovascular effects of beta2-agonists, including tachycardia and ventricular arrhythmias. Both drug classes can prolong QTc interval, although inhaled olodaterol at recommended doses has low systemic exposure.
What this interaction means in plain words
Olodaterol inhaled and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on cardiac repolarization and heart rate via tricyclic noradrenergic and sodium-channel effects plus beta2-agonist stimulation.
What to do
Use olodaterol at the labeled dose only and monitor for palpitations and arrhythmia. Check ECG and potassium in patients with cardiac disease or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Olodaterol inhaled with Trimipramine?
MediHelp rates the interaction as moderate. Olodaterol inhaled and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tricyclic antidepressants can potentiate the cardiovascular effects of beta2-agonists, including tachycardia and ventricular arrhythmias. Both drug classes can prolong QTc interval, although inhaled olodaterol at recommended doses has low systemic exposure.
How serious is the interaction between Olodaterol inhaled and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use olodaterol at the labeled dose only and monitor for palpitations and arrhythmia. Check ECG and potassium in patients with cardiac disease or other QT-prolonging drugs.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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