Drug interactions
Olopatadine intranasal + Oxycodone
Severity: Moderate
Olopatadine intranasal and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Intranasal olopatadine can cause somnolence, and combining it with opioids may add to drowsiness and psychomotor impairment. Systemic exposure is limited, so the effect is generally modest.
What this interaction means in plain words
Olopatadine intranasal and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects of a sedating antihistamine with an opioid.
What to do
Counsel patients about additive drowsiness and avoid driving until response is known. Consider a non-sedating nasal alternative if sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Frequently asked questions
Can I take Olopatadine intranasal with Oxycodone?
MediHelp rates the interaction as moderate. Olopatadine intranasal and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Intranasal olopatadine can cause somnolence, and combining it with opioids may add to drowsiness and psychomotor impairment. Systemic exposure is limited, so the effect is generally modest.
How serious is the interaction between Olopatadine intranasal and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients about additive drowsiness and avoid driving until response is known. Consider a non-sedating nasal alternative if sedation occurs.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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