Drug interactions
Olutasidenib + Sirolimus
Severity: Major
Olutasidenib and Sirolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olutasidenib induces CYP3A4 and may lower sirolimus concentrations. Reduced exposure risks loss of immunosuppression and graft rejection.
What this interaction means in plain words
Olutasidenib and Sirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Olutasidenib belongs to Oncology; Sirolimus belongs to Miscellaneous.
Why it happens
Induction of CYP3A4 increases sirolimus metabolism.
What to do
Avoid if possible. If unavoidable, monitor sirolimus trough levels and increase dose as needed, with rejection surveillance.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Olutasidenib
Frequently asked questions
Can I take Olutasidenib with Sirolimus?
MediHelp rates the interaction as major. Olutasidenib and Sirolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Olutasidenib induces CYP3A4 and may lower sirolimus concentrations. Reduced exposure risks loss of immunosuppression and graft rejection.
How serious is the interaction between Olutasidenib and Sirolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If unavoidable, monitor sirolimus trough levels and increase dose as needed, with rejection surveillance.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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