Drug interactions
Olutasidenib + Tacrolimus
Severity: Major
Olutasidenib and Tacrolimus: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Olutasidenib induces CYP3A4 and may lower tacrolimus concentrations. Subtherapeutic tacrolimus raises the risk of graft rejection or graft-versus-host disease.
What this interaction means in plain words
Olutasidenib and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Olutasidenib belongs to Oncology; Tacrolimus belongs to Miscellaneous.
Why it happens
Induction of CYP3A4 increases the metabolic clearance of tacrolimus.
What to do
Avoid if possible. If needed, monitor tacrolimus trough concentrations frequently and increase the dose as required, and reduce it again after olutasidenib is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Olutasidenib
Frequently asked questions
Can I take Olutasidenib with Tacrolimus?
MediHelp rates the interaction as major. Olutasidenib and Tacrolimus can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Olutasidenib induces CYP3A4 and may lower tacrolimus concentrations. Subtherapeutic tacrolimus raises the risk of graft rejection or graft-versus-host disease.
How serious is the interaction between Olutasidenib and Tacrolimus?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible. If needed, monitor tacrolimus trough concentrations frequently and increase the dose as required, and reduce it again after olutasidenib is stopped.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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