Drug interactions
Omadacycline + Oxacillin
Severity: Moderate
Omadacycline and Oxacillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bacteriostatic tetracyclines may blunt the bactericidal effect of penicillins, which depend on actively dividing bacteria. The clinical significance is uncertain, but it may matter in severe staphylococcal infections.
What this interaction means in plain words
Omadacycline and Oxacillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Omadacycline belongs to Anti Bacterial; Oxacillin belongs to Anti Bacterial.
Why it happens
Tetracycline-induced inhibition of bacterial protein synthesis and growth reduces the activity of cell-wall-active beta-lactams.
What to do
Avoid the combination in serious infections requiring bactericidal activity. If both are needed, monitor clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxacillin
- Bcg vaccine live + Oxacillin Moderate
- Chloramphenicol + Oxacillin Moderate
- Cholera vaccine + Oxacillin Moderate
- Demeclocycline + Oxacillin Moderate
- Doxycycline + Oxacillin Moderate
- Microbiota + Oxacillin Moderate
Other interactions of Omadacycline
- Acitretin + Omadacycline Contraindicated
- Isotretinoin + Omadacycline Major
- Omadacycline + Tretinoin Major
- Aluminum hydroxide + Omadacycline Moderate
- Amoxicillin-clavulanic acid + Omadacycline Moderate
- Amoxicillin + Omadacycline Moderate
Frequently asked questions
Can I take Omadacycline with Oxacillin?
MediHelp rates the interaction as moderate. Omadacycline and Oxacillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bacteriostatic tetracyclines may blunt the bactericidal effect of penicillins, which depend on actively dividing bacteria. The clinical significance is uncertain, but it may matter in severe staphylococcal infections.
How serious is the interaction between Omadacycline and Oxacillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination in serious infections requiring bactericidal activity. If both are needed, monitor clinical response.
What other medicines interact with Oxacillin?
MediHelp also lists interactions of Oxacillin with, for example, Bcg vaccine live, Chloramphenicol, Cholera vaccine. The full list is on the Oxacillin page.
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