Drug interactions
Omaveloxolone + Pimozide
Severity: Moderate
Omaveloxolone and Pimozide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omaveloxolone may induce CYP3A4 and lower exposure to sensitive substrates such as pimozide. Reduced pimozide levels could cause loss of efficacy.
What this interaction means in plain words
Omaveloxolone and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Omaveloxolone belongs to Central Nervous System; Pimozide belongs to Central Nervous System.
Why it happens
Weak to moderate induction of CYP3A4 by omaveloxolone, which increases pimozide clearance.
What to do
Monitor for reduced pimozide effect and adjust the dose to clinical response with ECG oversight. Reassess if omaveloxolone is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Omaveloxolone with Pimozide?
MediHelp rates the interaction as moderate. Omaveloxolone and Pimozide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Omaveloxolone may induce CYP3A4 and lower exposure to sensitive substrates such as pimozide. Reduced pimozide levels could cause loss of efficacy.
How serious is the interaction between Omaveloxolone and Pimozide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced pimozide effect and adjust the dose to clinical response with ECG oversight. Reassess if omaveloxolone is stopped.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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