Drug interactions
Omaveloxolone + Theophylline
Severity: Minor
Omaveloxolone and Theophylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Omaveloxolone may weakly induce CYP3A4, which could modestly lower exposure to CYP3A4 substrates. Theophylline is mainly cleared by CYP1A2, so the effect is likely small.
What this interaction means in plain words
Omaveloxolone and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Omaveloxolone belongs to Central Nervous System; Theophylline belongs to Respiratory.
Why it happens
Weak CYP3A4 induction by omaveloxolone may slightly increase a minor theophylline clearance pathway.
What to do
No routine adjustment is needed; monitor theophylline response and levels if efficacy appears reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Omaveloxolone
Frequently asked questions
Can I take Omaveloxolone with Theophylline?
MediHelp rates the interaction as minor. Omaveloxolone and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Omaveloxolone may weakly induce CYP3A4, which could modestly lower exposure to CYP3A4 substrates. Theophylline is mainly cleared by CYP1A2, so the effect is likely small.
How serious is the interaction between Omaveloxolone and Theophylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor theophylline response and levels if efficacy appears reduced.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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