Drug interactions
Omeprazole + Oxcarbazepine
Severity: Minor
Omeprazole and Oxcarbazepine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine can induce CYP3A4 and inhibit CYP2C19, giving an unpredictable effect on omeprazole exposure. Any change is typically small.
What this interaction means in plain words
Omeprazole and Oxcarbazepine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Omeprazole belongs to Gastrointestinal Tract; Oxcarbazepine belongs to Central Nervous System.
Why it happens
Oxcarbazepine's active metabolite modulates CYP2C19 and CYP3A4 activity.
What to do
No routine adjustment; watch for loss of acid suppression or omeprazole adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Frequently asked questions
Can I take Omeprazole with Oxcarbazepine?
MediHelp rates the interaction as minor. Omeprazole and Oxcarbazepine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oxcarbazepine can induce CYP3A4 and inhibit CYP2C19, giving an unpredictable effect on omeprazole exposure. Any change is typically small.
How serious is the interaction between Omeprazole and Oxcarbazepine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; watch for loss of acid suppression or omeprazole adverse effects.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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