Drug interactions
Omeprazole + Pazopanib
Severity: Major
Omeprazole and Pazopanib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib absorption is pH dependent, and PPIs can reduce its exposure and potentially its antitumor efficacy.
What this interaction means in plain words
Omeprazole and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Omeprazole belongs to Gastrointestinal Tract; Pazopanib belongs to Oncology.
Why it happens
Elevated gastric pH reduces pazopanib solubility and absorption.
What to do
Avoid PPIs; if acid suppression is needed, use a short-acting antacid separated by several hours or an H2 antagonist with appropriate timing, and monitor tumor response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Omeprazole with Pazopanib?
MediHelp rates the interaction as major. Omeprazole and Pazopanib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pazopanib absorption is pH dependent, and PPIs can reduce its exposure and potentially its antitumor efficacy.
How serious is the interaction between Omeprazole and Pazopanib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs; if acid suppression is needed, use a short-acting antacid separated by several hours or an H2 antagonist with appropriate timing, and monitor tumor response.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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