Drug interactions
Omeprazole + Primidone
Severity: Moderate
Omeprazole and Primidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone, which is partly converted to phenobarbital, induces drug-metabolizing enzymes and can lower omeprazole concentrations. Reduced acid suppression may result.
What this interaction means in plain words
Omeprazole and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Omeprazole belongs to Gastrointestinal Tract; Primidone belongs to Central Nervous System.
Why it happens
Induction of CYP2C19 and CYP3A4 increases omeprazole clearance.
What to do
Watch for inadequate acid control and increase the omeprazole dose or change therapy if symptoms persist.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Omeprazole with Primidone?
MediHelp rates the interaction as moderate. Omeprazole and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone, which is partly converted to phenobarbital, induces drug-metabolizing enzymes and can lower omeprazole concentrations. Reduced acid suppression may result.
How serious is the interaction between Omeprazole and Primidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for inadequate acid control and increase the omeprazole dose or change therapy if symptoms persist.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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