Drug interactions
Omeprazole + Siponimod
Severity: Minor
Omeprazole and Siponimod: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Siponimod is metabolized by CYP2C9 and CYP3A4. Omeprazole is mainly a CYP2C19 inhibitor with little CYP2C9 inhibition, so a clinically important increase in siponimod exposure is unlikely.
What this interaction means in plain words
Omeprazole and Siponimod have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Omeprazole belongs to Gastrointestinal Tract; Siponimod belongs to Central Nervous System.
Why it happens
Omeprazole may weakly inhibit CYP2C9, with a minimal predicted effect on siponimod.
What to do
No dose adjustment is needed; check CYP2C9 genotype requirements per siponimod labeling.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Frequently asked questions
Can I take Omeprazole with Siponimod?
MediHelp rates the interaction as minor. Omeprazole and Siponimod have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Siponimod is metabolized by CYP2C9 and CYP3A4. Omeprazole is mainly a CYP2C19 inhibitor with little CYP2C9 inhibition, so a clinically important increase in siponimod exposure is unlikely.
How serious is the interaction between Omeprazole and Siponimod?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; check CYP2C9 genotype requirements per siponimod labeling.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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