Drug interactions
Omeprazole + Sotorasib
Severity: Major
Omeprazole and Sotorasib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Acid-reducing drugs lower sotorasib absorption, which may reduce its anticancer effect. Proton pump inhibitors have the greatest effect because of their prolonged acid suppression.
What this interaction means in plain words
Omeprazole and Sotorasib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Omeprazole belongs to Gastrointestinal Tract; Sotorasib belongs to Oncology.
Why it happens
Omeprazole raises gastric pH, which reduces the pH-dependent solubility and absorption of sotorasib.
What to do
Avoid PPIs with sotorasib. If acid suppression is needed, use a locally acting antacid, taking sotorasib 4 hours before or 10 hours after it.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Omeprazole
- Mavacamten + Omeprazole Contraindicated
- Omeprazole + Rilpivirine Contraindicated
- Acalabrutinib + Omeprazole Major
- Atazanavir + Omeprazole Major
- Citalopram + Omeprazole Major
- Clopidogrel + Omeprazole Major
Other interactions of Sotorasib
- Amobarbital + Sotorasib Major
- Apalutamide + Sotorasib Major
- Carbamazepine + Sotorasib Major
- Colchicine + Sotorasib Major
- Cyclosporin + Sotorasib Major
- Digoxin + Sotorasib Major
Frequently asked questions
Can I take Omeprazole with Sotorasib?
MediHelp rates the interaction as major. Omeprazole and Sotorasib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Acid-reducing drugs lower sotorasib absorption, which may reduce its anticancer effect. Proton pump inhibitors have the greatest effect because of their prolonged acid suppression.
How serious is the interaction between Omeprazole and Sotorasib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid PPIs with sotorasib. If acid suppression is needed, use a locally acting antacid, taking sotorasib 4 hours before or 10 hours after it.
What other medicines interact with Omeprazole?
MediHelp also lists interactions of Omeprazole with, for example, Mavacamten, Rilpivirine, Acalabrutinib. The full list is on the Omeprazole page.
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