Drug interactions
Ondansetron + Peginterferon alfa 2a
Severity: Minor
Ondansetron and Peginterferon alfa 2a: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Peginterferon alfa-2a can inhibit CYP1A2 and may slightly raise ondansetron exposure. Since ondansetron has multiple clearance pathways, the effect is likely to be minimal.
What this interaction means in plain words
Ondansetron and Peginterferon alfa 2a have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ondansetron belongs to Gastrointestinal Tract; Peginterferon alfa 2a belongs to Anti Virals.
Why it happens
Peginterferon alfa-2a reduces CYP1A2 activity, slowing one route of ondansetron metabolism.
What to do
No dose adjustment is required. Monitor for ondansetron adverse effects such as headache, constipation or QT prolongation if other risk factors are present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ondansetron and Peginterferon alfa 2a, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Peginterferon alfa 2a
Frequently asked questions
Can I take Ondansetron with Peginterferon alfa 2a?
MediHelp rates the interaction as minor. Ondansetron and Peginterferon alfa 2a have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Peginterferon alfa-2a can inhibit CYP1A2 and may slightly raise ondansetron exposure. Since ondansetron has multiple clearance pathways, the effect is likely to be minimal.
How serious is the interaction between Ondansetron and Peginterferon alfa 2a?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. Monitor for ondansetron adverse effects such as headache, constipation or QT prolongation if other risk factors are present.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
