Drug interactions
Ondansetron + Ponatinib
Severity: Minor
Ondansetron and Ponatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ponatinib inhibits P-glycoprotein in vitro and may raise exposure to ondansetron, a P-gp substrate. Ponatinib itself carries QT-related concerns, though the main concern here is a modest increase in ondansetron exposure.
What this interaction means in plain words
Ondansetron and Ponatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ondansetron belongs to Gastrointestinal Tract; Ponatinib belongs to Oncology.
Why it happens
Inhibition of P-glycoprotein efflux by ponatinib may increase ondansetron exposure.
What to do
No dose adjustment is usually needed. Monitor for ondansetron adverse effects and check an ECG if there are QT risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Other interactions of Ponatinib
Frequently asked questions
Can I take Ondansetron with Ponatinib?
MediHelp rates the interaction as minor. Ondansetron and Ponatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ponatinib inhibits P-glycoprotein in vitro and may raise exposure to ondansetron, a P-gp substrate. Ponatinib itself carries QT-related concerns, though the main concern here is a modest increase in ondansetron exposure.
How serious is the interaction between Ondansetron and Ponatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Monitor for ondansetron adverse effects and check an ECG if there are QT risk factors.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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