Drug interactions
Ondansetron + Romidepsin
Severity: Major
Ondansetron and Romidepsin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Romidepsin is associated with ECG changes including QT prolongation, and ondansetron can also lengthen the QT interval. Combined use may raise the risk of ventricular arrhythmia, particularly because antiemetics are routinely given with romidepsin.
What this interaction means in plain words
Ondansetron and Romidepsin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Check and correct potassium and magnesium before each romidepsin dose and obtain baseline ECG. Consider a non-QT-prolonging antiemetic in patients with cardiac risk factors.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Frequently asked questions
Can I take Ondansetron with Romidepsin?
MediHelp rates the interaction as major. Ondansetron and Romidepsin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Romidepsin is associated with ECG changes including QT prolongation, and ondansetron can also lengthen the QT interval. Combined use may raise the risk of ventricular arrhythmia, particularly because antiemetics are routinely given with romidepsin.
How serious is the interaction between Ondansetron and Romidepsin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check and correct potassium and magnesium before each romidepsin dose and obtain baseline ECG. Consider a non-QT-prolonging antiemetic in patients with cardiac risk factors.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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