Drug interactions
Ondansetron + Selegiline transdermal
Severity: Moderate
Ondansetron and Selegiline transdermal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ondansetron has been associated with serotonin syndrome when combined with serotonergic drugs. Selegiline is an MAO inhibitor, and at transdermal doses used for depression it carries a serotonin toxicity risk with serotonergic agents, though evidence for this specific pairing is limited.
What this interaction means in plain words
Ondansetron and Selegiline transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive serotonergic effect from MAO inhibition combined with 5-HT3 antagonism; the mechanism is not firmly established.
What to do
Monitor for agitation, tremor, clonus, hyperthermia and autonomic instability when ondansetron is started. Stop both and treat supportively if serotonin syndrome develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Frequently asked questions
Can I take Ondansetron with Selegiline transdermal?
MediHelp rates the interaction as moderate. Ondansetron and Selegiline transdermal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ondansetron has been associated with serotonin syndrome when combined with serotonergic drugs. Selegiline is an MAO inhibitor, and at transdermal doses used for depression it carries a serotonin toxicity risk with serotonergic agents, though evidence for this specific pairing is limited.
How serious is the interaction between Ondansetron and Selegiline transdermal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for agitation, tremor, clonus, hyperthermia and autonomic instability when ondansetron is started. Stop both and treat supportively if serotonin syndrome develops.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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