Drug interactions
Ondansetron + Sumatriptan intranasal
Severity: Moderate
Ondansetron and Sumatriptan intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both 5-HT3 antagonists and triptans have been reported with serotonin syndrome in combination, although cases are rare. In practice the pair is often used together to treat migraine with nausea.
What this interaction means in plain words
Ondansetron and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive serotonergic effect from 5-HT1B/1D agonism and 5-HT3 antagonism; the mechanism is not firmly established.
What to do
The combination can generally be used with awareness of symptoms. Counsel the patient to seek care for agitation, tremor, sweating, fever or muscle rigidity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Frequently asked questions
Can I take Ondansetron with Sumatriptan intranasal?
MediHelp rates the interaction as moderate. Ondansetron and Sumatriptan intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both 5-HT3 antagonists and triptans have been reported with serotonin syndrome in combination, although cases are rare. In practice the pair is often used together to treat migraine with nausea.
How serious is the interaction between Ondansetron and Sumatriptan intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: The combination can generally be used with awareness of symptoms. Counsel the patient to seek care for agitation, tremor, sweating, fever or muscle rigidity.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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