Drug interactions
Ondansetron + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Ondansetron and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a long-acting beta-agonist, can cause cardiovascular effects including QT prolongation at high exposure. Ondansetron may add to this, though systemic vilanterol levels from inhalation are low.
What this interaction means in plain words
Ondansetron and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive QT prolongation and adrenergic cardiac effects.
What to do
The combination can generally be used with monitoring for palpitations or syncope. Obtain an ECG and check electrolytes in patients with cardiac disease or other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Frequently asked questions
Can I take Ondansetron with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Ondansetron and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol, a long-acting beta-agonist, can cause cardiovascular effects including QT prolongation at high exposure. Ondansetron may add to this, though systemic vilanterol levels from inhalation are low.
How serious is the interaction between Ondansetron and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: The combination can generally be used with monitoring for palpitations or syncope. Obtain an ECG and check electrolytes in patients with cardiac disease or other QT risk factors.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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