Drug interactions
Ondansetron + Vilanterol / fluticasone furoate inhaled
Severity: Moderate
Ondansetron and Vilanterol / fluticasone furoate inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol is a long-acting beta-agonist that can cause adrenergic cardiovascular effects, and ondansetron can prolong the QT interval. Systemic vilanterol exposure from inhalation is low, so the clinical effect is likely limited.
What this interaction means in plain words
Ondansetron and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive QT prolongation and adrenergic cardiac effects.
What to do
Use together with monitoring for palpitations and arrhythmia. Check ECG and electrolytes in patients with cardiac disease or other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ondansetron
- Apomorphine + Ondansetron Contraindicated
- Ondansetron + Thioridazine Contraindicated
- Ondansetron + Vandetanib Contraindicated
- Adagrasib + Ondansetron Major
- Amiodarone + Ondansetron Major
- Amisulpride + Ondansetron Major
Frequently asked questions
Can I take Ondansetron with Vilanterol / fluticasone furoate inhaled?
MediHelp rates the interaction as moderate. Ondansetron and Vilanterol / fluticasone furoate inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol is a long-acting beta-agonist that can cause adrenergic cardiovascular effects, and ondansetron can prolong the QT interval. Systemic vilanterol exposure from inhalation is low, so the clinical effect is likely limited.
How serious is the interaction between Ondansetron and Vilanterol / fluticasone furoate inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use together with monitoring for palpitations and arrhythmia. Check ECG and electrolytes in patients with cardiac disease or other QT risk factors.
What other medicines interact with Ondansetron?
MediHelp also lists interactions of Ondansetron with, for example, Apomorphine, Thioridazine, Vandetanib. The full list is on the Ondansetron page.
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