Drug interactions
Opium tincture + Trimipramine
Severity: Major
Opium tincture and Trimipramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids and sedating tricyclics both depress the CNS, and their combination can cause profound sedation, respiratory depression and hypotension. Constipation and urinary retention may also be intensified by trimipramine's anticholinergic effects.
What this interaction means in plain words
Opium tincture and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS and respiratory depression, with additive anticholinergic effects on gut and bladder.
What to do
Use the lowest effective opioid dose and monitor sedation and respiratory rate, especially at initiation. Warn against alcohol and other sedatives and consider a bowel regimen.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Opium tincture with Trimipramine?
MediHelp rates the interaction as major. Opium tincture and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids and sedating tricyclics both depress the CNS, and their combination can cause profound sedation, respiratory depression and hypotension. Constipation and urinary retention may also be intensified by trimipramine's anticholinergic effects.
How serious is the interaction between Opium tincture and Trimipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective opioid dose and monitor sedation and respiratory rate, especially at initiation. Warn against alcohol and other sedatives and consider a bowel regimen.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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