Drug interactions
Oritavancin + Valproic acid
Severity: Minor
Oritavancin and Valproic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oritavancin is a weak inhibitor of CYP2C19, which contributes only a minor share of valproate metabolism. A meaningful rise in valproate concentrations is therefore unlikely.
What this interaction means in plain words
Oritavancin and Valproic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Oritavancin belongs to Anti Bacterial; Valproic acid belongs to Central Nervous System.
Why it happens
Weak CYP2C19 inhibition by oritavancin affecting a minor valproate metabolic pathway.
What to do
No empiric dose change is needed. Monitor for valproate adverse effects or check a level if toxicity is suspected.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Valproic acid
- Ertapenem + Valproic acid Contraindicated
- Imipenem / cilastatin / relebactam + Valproic acid Contraindicated
- Imipenem / cilastatin + Valproic acid Contraindicated
- Meropenem / vaborbactam + Valproic acid Contraindicated
- Meropenem + Valproic acid Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Valproic acid Major
Other interactions of Oritavancin
- Heparin + Oritavancin Contraindicated
- Oritavancin + Warfarin Moderate
- Carbamazepine + Oritavancin Minor
- Cyclosporin + Oritavancin Minor
- Ethosuximide + Oritavancin Minor
- Flecainide + Oritavancin Minor
Frequently asked questions
Can I take Oritavancin with Valproic acid?
MediHelp rates the interaction as minor. Oritavancin and Valproic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oritavancin is a weak inhibitor of CYP2C19, which contributes only a minor share of valproate metabolism. A meaningful rise in valproate concentrations is therefore unlikely.
How serious is the interaction between Oritavancin and Valproic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed. Monitor for valproate adverse effects or check a level if toxicity is suspected.
What other medicines interact with Valproic acid?
MediHelp also lists interactions of Valproic acid with, for example, Ertapenem, Imipenem / cilastatin / relebactam, Imipenem / cilastatin. The full list is on the Valproic acid page.
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