Drug interactions
Orlistat + Tipranavir
Severity: Moderate
Orlistat and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loss of virological control has been reported in HIV-infected patients who took orlistat together with antiretroviral therapy. Orlistat may reduce systemic exposure to tipranavir, which could allow viral rebound and resistance to develop.
What this interaction means in plain words
Orlistat and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Orlistat belongs to Miscellaneous; Tipranavir belongs to Anti Virals.
Why it happens
Orlistat's fat-malabsorptive effect in the gut may reduce absorption of the lipophilic oral antiretroviral, although the exact mechanism is not established.
What to do
Avoid the combination where possible, or monitor HIV RNA closely. Stop orlistat if viral load rises and the increase is confirmed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orlistat
- Cyclosporine + Orlistat Major
- Cyclosporin + Orlistat Major
- Orlistat + Triheptanoin Major
- Amiodarone + Orlistat Moderate
- Beta carotene + Orlistat Moderate
- Carbamazepine + Orlistat Moderate
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Orlistat with Tipranavir?
MediHelp rates the interaction as moderate. Orlistat and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loss of virological control has been reported in HIV-infected patients who took orlistat together with antiretroviral therapy. Orlistat may reduce systemic exposure to tipranavir, which could allow viral rebound and resistance to develop.
How serious is the interaction between Orlistat and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, or monitor HIV RNA closely. Stop orlistat if viral load rises and the increase is confirmed.
What other medicines interact with Orlistat?
MediHelp also lists interactions of Orlistat with, for example, Cyclosporine, Cyclosporin, Triheptanoin. The full list is on the Orlistat page.
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