Drug interactions
Orphenadrin + Oxymorphone
Severity: Major
Orphenadrin and Oxymorphone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine can enhance the sedative and respiratory depressant effects of oxymorphone. Anticholinergic effects may add constipation and urinary retention.
What this interaction means in plain words
Orphenadrin and Oxymorphone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Orphenadrin belongs to Musculoskeletal; Oxymorphone belongs to Musculoskeletal.
Why it happens
Additive central nervous system and respiratory depression.
What to do
Avoid if possible; otherwise use the lowest effective doses and monitor sedation and respiratory rate closely, particularly at start or dose changes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Orphenadrin
Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Frequently asked questions
Can I take Orphenadrin with Oxymorphone?
MediHelp rates the interaction as major. Orphenadrin and Oxymorphone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Orphenadrine can enhance the sedative and respiratory depressant effects of oxymorphone. Anticholinergic effects may add constipation and urinary retention.
How serious is the interaction between Orphenadrin and Oxymorphone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise use the lowest effective doses and monitor sedation and respiratory rate closely, particularly at start or dose changes.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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