Drug interactions
Orphenadrin + Pilocarpine
Severity: Moderate
Orphenadrin and Pilocarpine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pilocarpine stimulates muscarinic receptors while orphenadrine blocks them, so the two oppose one another. The anticholinergic may reduce pilocarpine's benefit for dry mouth or glaucoma.
What this interaction means in plain words
Orphenadrin and Pilocarpine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Orphenadrin belongs to Musculoskeletal; Pilocarpine belongs to Miscellaneous.
Why it happens
Pharmacodynamic antagonism at muscarinic receptors.
What to do
Monitor for loss of pilocarpine efficacy and consider an alternative muscle relaxant without anticholinergic activity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Pilocarpine
- Amitriptyline + Pilocarpine Moderate
- Atenolol-chlorthalidone + Pilocarpine Moderate
- Atenolol + Pilocarpine Moderate
- Atropine + Pilocarpine Moderate
- Betaxolol + Pilocarpine Moderate
- Bethanechol + Pilocarpine Moderate
Frequently asked questions
Can I take Orphenadrin with Pilocarpine?
MediHelp rates the interaction as moderate. Orphenadrin and Pilocarpine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pilocarpine stimulates muscarinic receptors while orphenadrine blocks them, so the two oppose one another. The anticholinergic may reduce pilocarpine's benefit for dry mouth or glaucoma.
How serious is the interaction between Orphenadrin and Pilocarpine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of pilocarpine efficacy and consider an alternative muscle relaxant without anticholinergic activity.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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