Drug interactions
Orphenadrin + Secobarbital
Severity: Moderate
Orphenadrin and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital is a potent sedative-hypnotic and orphenadrine adds CNS depression. The combination can cause excessive sedation, impaired coordination and respiratory depression.
What this interaction means in plain words
Orphenadrin and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Orphenadrin belongs to Musculoskeletal; Secobarbital belongs to Central Nervous System.
Why it happens
Additive CNS depression.
What to do
Use the lowest effective doses and avoid alcohol and other sedatives. Monitor sedation and respiratory status, especially in older or frail patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Orphenadrin with Secobarbital?
MediHelp rates the interaction as moderate. Orphenadrin and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital is a potent sedative-hypnotic and orphenadrine adds CNS depression. The combination can cause excessive sedation, impaired coordination and respiratory depression.
How serious is the interaction between Orphenadrin and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and avoid alcohol and other sedatives. Monitor sedation and respiratory status, especially in older or frail patients.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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