Drug interactions
Orphenadrin + Sufentanil
Severity: Major
Orphenadrin and Sufentanil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sufentanil is a very potent opioid, and orphenadrine adds to CNS depression. Profound sedation and respiratory depression may result.
What this interaction means in plain words
Orphenadrin and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Orphenadrin belongs to Musculoskeletal; Sufentanil belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression.
What to do
Use reduced sufentanil doses and monitor sedation, respiratory rate and oxygen saturation continuously in monitored settings.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Orphenadrin
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Orphenadrin with Sufentanil?
MediHelp rates the interaction as major. Orphenadrin and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Sufentanil is a very potent opioid, and orphenadrine adds to CNS depression. Profound sedation and respiratory depression may result.
How serious is the interaction between Orphenadrin and Sufentanil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use reduced sufentanil doses and monitor sedation, respiratory rate and oxygen saturation continuously in monitored settings.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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