Drug interactions
Orphenadrine + Oxycodone
Severity: Major
Orphenadrine and Oxycodone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine is a sedating anticholinergic muscle relaxant that adds to opioid CNS depression. Drowsiness, confusion, impaired psychomotor performance and respiratory depression are possible, with anticholinergic effects such as constipation and urinary retention adding to opioid effects.
What this interaction means in plain words
Orphenadrine and Oxycodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive CNS depression and additive anticholinergic effects.
What to do
Avoid combining if alternatives exist; otherwise use lower doses and monitor sedation, respiratory status and bowel/bladder function, especially in older adults.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Frequently asked questions
Can I take Orphenadrine with Oxycodone?
MediHelp rates the interaction as major. Orphenadrine and Oxycodone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Orphenadrine is a sedating anticholinergic muscle relaxant that adds to opioid CNS depression. Drowsiness, confusion, impaired psychomotor performance and respiratory depression are possible, with anticholinergic effects such as constipation and urinary retention adding to opioid effects.
How serious is the interaction between Orphenadrine and Oxycodone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining if alternatives exist; otherwise use lower doses and monitor sedation, respiratory status and bowel/bladder function, especially in older adults.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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