Drug interactions
Orphenadrine + Risperidone
Severity: Moderate
Orphenadrine and Risperidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine is an anticholinergic muscle relaxant that causes drowsiness, dizziness and confusion, which can add to risperidone's sedation. Additive anticholinergic effects such as urinary retention and constipation are also possible, particularly in older adults.
What this interaction means in plain words
Orphenadrine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and anticholinergic effects.
What to do
Use the lowest effective orphenadrine dose for a short course. Monitor for oversedation, confusion and anticholinergic effects, especially in older patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Risperidone
- Ibutilide + Risperidone Contraindicated
- Risperidone + Vandetanib Contraindicated
- Adagrasib + Risperidone Major
- Amiodarone + Risperidone Major
- Amisulpride + Risperidone Major
- Amoxapine + Risperidone Major
Frequently asked questions
Can I take Orphenadrine with Risperidone?
MediHelp rates the interaction as moderate. Orphenadrine and Risperidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orphenadrine is an anticholinergic muscle relaxant that causes drowsiness, dizziness and confusion, which can add to risperidone's sedation. Additive anticholinergic effects such as urinary retention and constipation are also possible, particularly in older adults.
How serious is the interaction between Orphenadrine and Risperidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective orphenadrine dose for a short course. Monitor for oversedation, confusion and anticholinergic effects, especially in older patients.
What other medicines interact with Risperidone?
MediHelp also lists interactions of Risperidone with, for example, Ibutilide, Vandetanib, Adagrasib. The full list is on the Risperidone page.
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