Drug interactions
Orphenadrine + Trazodone
Severity: Moderate
Orphenadrine and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine is a sedating anticholinergic muscle relaxant, and trazodone adds sedation and weak anticholinergic effects. The combination may increase drowsiness, confusion, dry mouth and urinary retention, especially in the elderly.
What this interaction means in plain words
Orphenadrine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and antimuscarinic effects.
What to do
Use the lowest effective doses and monitor for sedation, confusion and anticholinergic symptoms. Avoid the combination in frail elderly patients where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Orphenadrine with Trazodone?
MediHelp rates the interaction as moderate. Orphenadrine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orphenadrine is a sedating anticholinergic muscle relaxant, and trazodone adds sedation and weak anticholinergic effects. The combination may increase drowsiness, confusion, dry mouth and urinary retention, especially in the elderly.
How serious is the interaction between Orphenadrine and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation, confusion and anticholinergic symptoms. Avoid the combination in frail elderly patients where possible.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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