Drug interactions
Orphenadrine + Trimipramine
Severity: Moderate
Orphenadrine and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Orphenadrine is a strongly anticholinergic muscle relaxant with sedative effects, and combining it with trimipramine increases antimuscarinic and CNS depressant burden. This may produce confusion, delirium, urinary retention, constipation, tachycardia and marked drowsiness.
What this interaction means in plain words
Orphenadrine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic and CNS depressant effects.
What to do
Monitor for anticholinergic toxicity and sedation, and use the lowest effective doses. Avoid in older patients or those with glaucoma, urinary retention or ileus.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Orphenadrine with Trimipramine?
MediHelp rates the interaction as moderate. Orphenadrine and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Orphenadrine is a strongly anticholinergic muscle relaxant with sedative effects, and combining it with trimipramine increases antimuscarinic and CNS depressant burden. This may produce confusion, delirium, urinary retention, constipation, tachycardia and marked drowsiness.
How serious is the interaction between Orphenadrine and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity and sedation, and use the lowest effective doses. Avoid in older patients or those with glaucoma, urinary retention or ileus.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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