Drug interactions
Osilodrostat + Pimavanserin
Severity: Moderate
Osilodrostat and Pimavanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval. Together they may increase the risk of torsades de pointes, particularly if the patient has hypokalemia, bradycardia or cardiac disease.
What this interaction means in plain words
Osilodrostat and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Osilodrostat belongs to Endocrine; Pimavanserin belongs to Central Nervous System.
Why it happens
Additive QT prolongation.
What to do
Obtain a baseline ECG and monitor it during treatment; correct potassium and magnesium abnormalities. Avoid the combination in patients with a prolonged QTc or other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Other interactions of Osilodrostat
Frequently asked questions
Can I take Osilodrostat with Pimavanserin?
MediHelp rates the interaction as moderate. Osilodrostat and Pimavanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval. Together they may increase the risk of torsades de pointes, particularly if the patient has hypokalemia, bradycardia or cardiac disease.
How serious is the interaction between Osilodrostat and Pimavanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it during treatment; correct potassium and magnesium abnormalities. Avoid the combination in patients with a prolonged QTc or other QT-prolonging drugs.
What other medicines interact with Pimavanserin?
MediHelp also lists interactions of Pimavanserin with, for example, Lefamulin, Pimozide, Vandetanib. The full list is on the Pimavanserin page.
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