Drug interactions
Osilodrostat + Quinine
Severity: Major
Osilodrostat and Quinine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs prolong the QT interval. Combined use raises the risk of torsades de pointes, particularly with hypokalemia, bradycardia or structural heart disease.
What this interaction means in plain words
Osilodrostat and Quinine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Osilodrostat belongs to Endocrine; Quinine belongs to Anti Parasitic.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Obtain a baseline ECG and monitor it during coadministration. Correct potassium and magnesium before and during therapy, and avoid the combination if the QTc is markedly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Osilodrostat
Frequently asked questions
Can I take Osilodrostat with Quinine?
MediHelp rates the interaction as major. Osilodrostat and Quinine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs prolong the QT interval. Combined use raises the risk of torsades de pointes, particularly with hypokalemia, bradycardia or structural heart disease.
How serious is the interaction between Osilodrostat and Quinine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor it during coadministration. Correct potassium and magnesium before and during therapy, and avoid the combination if the QTc is markedly prolonged.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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