Drug interactions
Osilodrostat + Salmeterol
Severity: Moderate
Osilodrostat and Salmeterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use may increase the risk of torsades de pointes. Osilodrostat can also cause hypokalemia, which adds to the risk.
What this interaction means in plain words
Osilodrostat and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Osilodrostat belongs to Endocrine; Salmeterol belongs to Respiratory.
Why it happens
Additive QTc prolongation, with possible hypokalemia contributing.
What to do
Obtain baseline and follow-up ECGs and correct potassium and magnesium before and during therapy. Reassess if QTc lengthens substantially.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Salmeterol
- Ritonavir + Salmeterol Contraindicated
- Salmeterol + Saquinavir Contraindicated
- Amitriptyline + Salmeterol Major
- Arformoterol + Salmeterol Major
- Atazanavir + Salmeterol Major
- Budesonide-formoterol + Salmeterol Major
Other interactions of Osilodrostat
Frequently asked questions
Can I take Osilodrostat with Salmeterol?
MediHelp rates the interaction as moderate. Osilodrostat and Salmeterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combined use may increase the risk of torsades de pointes. Osilodrostat can also cause hypokalemia, which adds to the risk.
How serious is the interaction between Osilodrostat and Salmeterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline and follow-up ECGs and correct potassium and magnesium before and during therapy. Reassess if QTc lengthens substantially.
What other medicines interact with Salmeterol?
MediHelp also lists interactions of Salmeterol with, for example, Ritonavir, Saquinavir, Amitriptyline. The full list is on the Salmeterol page.
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