Drug interactions
Osimertinib + Oxcarbazepine
Severity: Major
Osimertinib and Oxcarbazepine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxcarbazepine may lower osimertinib exposure through CYP3A4 induction. Strong inducers reduce osimertinib exposure, and oxcarbazepine is weaker. Reduced tumor control is possible.
What this interaction means in plain words
Osimertinib and Oxcarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Osimertinib belongs to Oncology; Oxcarbazepine belongs to Central Nervous System.
Why it happens
CYP3A4 induction increases osimertinib metabolism.
What to do
Prefer a non-inducing anticonvulsant. If it cannot be avoided, monitor tumor response.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxcarbazepine
- Cabotegravir + Oxcarbazepine Contraindicated
- Oxcarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Oxcarbazepine Major
- Atazanavir + Oxcarbazepine Major
- Benzhydrocodone / acetaminophen + Oxcarbazepine Major
- Bictegravir + Oxcarbazepine Major
Other interactions of Osimertinib
Frequently asked questions
Can I take Osimertinib with Oxcarbazepine?
MediHelp rates the interaction as major. Osimertinib and Oxcarbazepine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxcarbazepine may lower osimertinib exposure through CYP3A4 induction. Strong inducers reduce osimertinib exposure, and oxcarbazepine is weaker. Reduced tumor control is possible.
How serious is the interaction between Osimertinib and Oxcarbazepine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing anticonvulsant. If it cannot be avoided, monitor tumor response.
What other medicines interact with Oxcarbazepine?
MediHelp also lists interactions of Oxcarbazepine with, for example, Cabotegravir, Rilpivirine, Artemether / lumefantrine. The full list is on the Oxcarbazepine page.
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