Drug interactions
Osimertinib + Safinamide
Severity: Minor
Osimertinib and Safinamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Safinamide may inhibit intestinal BCRP, and osimertinib is a BCRP substrate, so osimertinib exposure could rise modestly. The clinical relevance is uncertain.
What this interaction means in plain words
Osimertinib and Safinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Osimertinib belongs to Oncology; Safinamide belongs to Central Nervous System.
Why it happens
Inhibition of intestinal BCRP efflux by safinamide may increase absorption of osimertinib.
What to do
No dose change is needed. Monitor for osimertinib adverse effects such as diarrhea, rash and QT prolongation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Other interactions of Osimertinib
Frequently asked questions
Can I take Osimertinib with Safinamide?
MediHelp rates the interaction as minor. Osimertinib and Safinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Safinamide may inhibit intestinal BCRP, and osimertinib is a BCRP substrate, so osimertinib exposure could rise modestly. The clinical relevance is uncertain.
How serious is the interaction between Osimertinib and Safinamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor for osimertinib adverse effects such as diarrhea, rash and QT prolongation.
What other medicines interact with Safinamide?
MediHelp also lists interactions of Safinamide with, for example, Amitriptyline, Amoxapine, Amphetamine polistirex. The full list is on the Safinamide page.
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