Drug interactions
Osimertinib + Sunitinib
Severity: Moderate
Osimertinib and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are associated with QT prolongation, so concurrent use may increase the risk of ventricular arrhythmia. Both can also cause cardiomyopathy and reduced ejection fraction.
What this interaction means in plain words
Osimertinib and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Osimertinib belongs to Oncology; Sunitinib belongs to Oncology.
Why it happens
Additive effects on cardiac repolarization; possible additive cardiac toxicity.
What to do
Perform periodic ECGs and monitor electrolytes, correcting hypokalemia and hypomagnesemia. Monitor cardiac function and interrupt therapy if significant QTc prolongation develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Other interactions of Osimertinib
Frequently asked questions
Can I take Osimertinib with Sunitinib?
MediHelp rates the interaction as moderate. Osimertinib and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents are associated with QT prolongation, so concurrent use may increase the risk of ventricular arrhythmia. Both can also cause cardiomyopathy and reduced ejection fraction.
How serious is the interaction between Osimertinib and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform periodic ECGs and monitor electrolytes, correcting hypokalemia and hypomagnesemia. Monitor cardiac function and interrupt therapy if significant QTc prolongation develops.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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