Drug interactions
Ospemifene + Spironolactone
Severity: Minor
Ospemifene and Spironolactone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are highly protein bound, so displacement is theoretically possible, but no clinically meaningful change in exposure has been established. The interaction is unlikely to matter in practice.
What this interaction means in plain words
Ospemifene and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ospemifene belongs to Endocrine; Spironolactone belongs to Cardiovascular.
Why it happens
Theoretical competition for plasma protein binding; clinically relevant effects are not established.
What to do
No specific action is needed beyond routine clinical monitoring.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Spironolactone
- Amiloride + Spironolactone Contraindicated
- Eplerenone + Spironolactone Contraindicated
- Spironolactone + Triamterene Contraindicated
- Abiraterone + Spironolactone Major
- Aceclofenac + Spironolactone Major
- Acemetacin + Spironolactone Major
Other interactions of Ospemifene
- Bazedoxifene-conjugated estrogens + Ospemifene Contraindicated
- Estradiol + Ospemifene Contraindicated
- Clomiphene + Ospemifene Major
- Fluconazole + Ospemifene Major
- Ketoconazole + Ospemifene Major
- Ospemifene + Raloxifene Major
Frequently asked questions
Can I take Ospemifene with Spironolactone?
MediHelp rates the interaction as minor. Ospemifene and Spironolactone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are highly protein bound, so displacement is theoretically possible, but no clinically meaningful change in exposure has been established. The interaction is unlikely to matter in practice.
How serious is the interaction between Ospemifene and Spironolactone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond routine clinical monitoring.
What other medicines interact with Spironolactone?
MediHelp also lists interactions of Spironolactone with, for example, Amiloride, Eplerenone, Triamterene. The full list is on the Spironolactone page.
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