Drug interactions
Oteseconazole + Sulphasalazine
Severity: Moderate
Oteseconazole and Sulphasalazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oteseconazole inhibits BCRP, which governs the intestinal efflux of sulfasalazine. Exposure to sulfasalazine may therefore rise, with greater risk of dose-related toxicity.
What this interaction means in plain words
Oteseconazole and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oteseconazole belongs to Anti Fungals; Sulphasalazine belongs to Gastrointestinal Tract.
Why it happens
Oteseconazole inhibits BCRP, reducing efflux of sulfasalazine and increasing its systemic exposure.
What to do
Use the lowest effective sulfasalazine dose and monitor for gastrointestinal, hematologic and hepatic adverse effects. Reduce the dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sulphasalazine
- Deferiprone + Sulphasalazine Major
- Pexidartinib + Sulphasalazine Major
- Sepiapterin + Sulphasalazine Major
- Acalabrutinib + Sulphasalazine Moderate
- Aceclofenac + Sulphasalazine Moderate
- Acetazolamide + Sulphasalazine Moderate
Other interactions of Oteseconazole
- Atorvastatin + Oteseconazole Moderate
- Fluvastatin + Oteseconazole Moderate
- Glyburide-metformin + Oteseconazole Moderate
- Glyburide + Oteseconazole Moderate
- Irinotecan + Oteseconazole Moderate
- Lapatinib + Oteseconazole Moderate
Frequently asked questions
Can I take Oteseconazole with Sulphasalazine?
MediHelp rates the interaction as moderate. Oteseconazole and Sulphasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oteseconazole inhibits BCRP, which governs the intestinal efflux of sulfasalazine. Exposure to sulfasalazine may therefore rise, with greater risk of dose-related toxicity.
How serious is the interaction between Oteseconazole and Sulphasalazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective sulfasalazine dose and monitor for gastrointestinal, hematologic and hepatic adverse effects. Reduce the dose if toxicity occurs.
What other medicines interact with Sulphasalazine?
MediHelp also lists interactions of Sulphasalazine with, for example, Deferiprone, Pexidartinib, Sepiapterin. The full list is on the Sulphasalazine page.
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