Drug interactions
Oxaliplatin + Palifermin
Severity: Major
Oxaliplatin and Palifermin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Palifermin stimulates epithelial cell growth, which may make mucosal cells more sensitive to cytotoxic chemotherapy when given close in time. Giving it within 24 hours of chemotherapy has been associated with worse and longer oral mucositis.
What this interaction means in plain words
Oxaliplatin and Palifermin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oxaliplatin belongs to Oncology; Palifermin belongs to Miscellaneous.
Why it happens
Palifermin-induced epithelial proliferation increases sensitivity of mucosal cells to cytotoxic agents.
What to do
Do not give palifermin within 24 hours before, during infusion of, or within 24 hours after oxaliplatin. Schedule doses outside this window.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Other interactions of Palifermin
Frequently asked questions
Can I take Oxaliplatin with Palifermin?
MediHelp rates the interaction as major. Oxaliplatin and Palifermin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Palifermin stimulates epithelial cell growth, which may make mucosal cells more sensitive to cytotoxic chemotherapy when given close in time. Giving it within 24 hours of chemotherapy has been associated with worse and longer oral mucositis.
How serious is the interaction between Oxaliplatin and Palifermin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give palifermin within 24 hours before, during infusion of, or within 24 hours after oxaliplatin. Schedule doses outside this window.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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