Drug interactions
Oxaliplatin + Pimavanserin
Severity: Major
Oxaliplatin and Pimavanserin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pimavanserin prolongs the QT interval and is cautioned against use with other QT-prolonging drugs. Oxaliplatin may add to this effect, increasing the risk of arrhythmia.
What this interaction means in plain words
Oxaliplatin and Pimavanserin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oxaliplatin belongs to Oncology; Pimavanserin belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic prolongation of the QT interval.
What to do
Perform baseline and periodic ECG monitoring and correct electrolyte abnormalities. Consider deferring pimavanserin or using an alternative if QTc becomes prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Other interactions of Pimavanserin
- Lefamulin + Pimavanserin Contraindicated
- Pimavanserin + Pimozide Contraindicated
- Pimavanserin + Vandetanib Contraindicated
- Adagrasib + Pimavanserin Major
- Amiodarone + Pimavanserin Major
- Amisulpride + Pimavanserin Major
Frequently asked questions
Can I take Oxaliplatin with Pimavanserin?
MediHelp rates the interaction as major. Oxaliplatin and Pimavanserin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pimavanserin prolongs the QT interval and is cautioned against use with other QT-prolonging drugs. Oxaliplatin may add to this effect, increasing the risk of arrhythmia.
How serious is the interaction between Oxaliplatin and Pimavanserin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Perform baseline and periodic ECG monitoring and correct electrolyte abnormalities. Consider deferring pimavanserin or using an alternative if QTc becomes prolonged.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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