Drug interactions
Oxaliplatin + Polymyxin b
Severity: Moderate
Oxaliplatin and Polymyxin b: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic polymyxin B is notably nephrotoxic and neurotoxic. Renal injury can reduce platinum elimination and may increase oxaliplatin toxicity, including neurotoxicity.
What this interaction means in plain words
Oxaliplatin and Polymyxin b can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxaliplatin belongs to Oncology; Polymyxin b belongs to Anti Bacterial.
Why it happens
Additive nephrotoxicity and neurotoxicity, with reduced renal clearance of platinum.
What to do
Monitor serum creatinine and electrolytes frequently and reduce oxaliplatin dose for renal impairment. Watch for worsening neuropathy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Other interactions of Polymyxin b
- Cidofovir + Polymyxin b Contraindicated
- Colistin + Polymyxin b Contraindicated
- Acyclovir + Polymyxin b Major
- Adefovir + Polymyxin b Major
- Amikacin + Polymyxin b Major
- Amphotericin b + Polymyxin b Major
Frequently asked questions
Can I take Oxaliplatin with Polymyxin b?
MediHelp rates the interaction as moderate. Oxaliplatin and Polymyxin b can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic polymyxin B is notably nephrotoxic and neurotoxic. Renal injury can reduce platinum elimination and may increase oxaliplatin toxicity, including neurotoxicity.
How serious is the interaction between Oxaliplatin and Polymyxin b?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and electrolytes frequently and reduce oxaliplatin dose for renal impairment. Watch for worsening neuropathy.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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