Drug interactions
Oxaliplatin + Promethazine
Severity: Moderate
Oxaliplatin and Promethazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaliplatin has been associated with QT prolongation, and promethazine is often used as an antiemetic with it. Combined use may add to arrhythmia risk, particularly with electrolyte losses from vomiting or diarrhea.
What this interaction means in plain words
Oxaliplatin and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxaliplatin belongs to Oncology; Promethazine belongs to Respiratory.
Why it happens
Additive QT prolongation, worsened by chemotherapy-related electrolyte disturbances.
What to do
Check potassium, magnesium and calcium and obtain an ECG in patients with additional QT risk factors. Consider an alternative antiemetic if QTc is prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Frequently asked questions
Can I take Oxaliplatin with Promethazine?
MediHelp rates the interaction as moderate. Oxaliplatin and Promethazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxaliplatin has been associated with QT prolongation, and promethazine is often used as an antiemetic with it. Combined use may add to arrhythmia risk, particularly with electrolyte losses from vomiting or diarrhea.
How serious is the interaction between Oxaliplatin and Promethazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check potassium, magnesium and calcium and obtain an ECG in patients with additional QT risk factors. Consider an alternative antiemetic if QTc is prolonged.
What other medicines interact with Promethazine?
MediHelp also lists interactions of Promethazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Promethazine page.
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