Drug interactions
Oxaliplatin + Sorafenib
Severity: Moderate
Oxaliplatin and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sorafenib can prolong the QT interval, and oxaliplatin has been linked to the same effect. Combined use may raise arrhythmia risk, especially with electrolyte disturbances.
What this interaction means in plain words
Oxaliplatin and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxaliplatin belongs to Oncology; Sorafenib belongs to Oncology.
Why it happens
Additive pharmacodynamic prolongation of cardiac repolarization.
What to do
Monitor ECG and electrolytes periodically, correcting potassium and magnesium. Reassess therapy if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Other interactions of Sorafenib
Frequently asked questions
Can I take Oxaliplatin with Sorafenib?
MediHelp rates the interaction as moderate. Oxaliplatin and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sorafenib can prolong the QT interval, and oxaliplatin has been linked to the same effect. Combined use may raise arrhythmia risk, especially with electrolyte disturbances.
How serious is the interaction between Oxaliplatin and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes periodically, correcting potassium and magnesium. Reassess therapy if QTc becomes markedly prolonged.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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