Drug interactions
Oxaliplatin + Sunitinib
Severity: Moderate
Oxaliplatin and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sunitinib can prolong the QT interval in a dose-dependent manner, and oxaliplatin may contribute to this effect. Combined use may increase the risk of ventricular arrhythmias.
What this interaction means in plain words
Oxaliplatin and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxaliplatin belongs to Oncology; Sunitinib belongs to Oncology.
Why it happens
Additive pharmacodynamic prolongation of the QT interval.
What to do
Monitor ECG and electrolytes at baseline and during therapy. Reduce or stop sunitinib if QTc becomes significantly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Oxaliplatin with Sunitinib?
MediHelp rates the interaction as moderate. Oxaliplatin and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sunitinib can prolong the QT interval in a dose-dependent manner, and oxaliplatin may contribute to this effect. Combined use may increase the risk of ventricular arrhythmias.
How serious is the interaction between Oxaliplatin and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes at baseline and during therapy. Reduce or stop sunitinib if QTc becomes significantly prolonged.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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