Drug interactions
Oxaliplatin + Tisagenlecleucel
Severity: Major
Oxaliplatin and Tisagenlecleucel: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaliplatin is myelosuppressive and immunosuppressive, and giving it around the time of CAR-T cell therapy may impair the expansion and persistence of the infused cells. It also adds to the infection risk from cytopenias after CAR-T therapy.
What this interaction means in plain words
Oxaliplatin and Tisagenlecleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Oxaliplatin belongs to Oncology; Tisagenlecleucel belongs to Oncology.
Why it happens
Cytotoxic chemotherapy can reduce the viability and expansion of the infused CAR-T cells and adds to immunosuppression and myelosuppression.
What to do
Avoid chemotherapy in the period shortly before and after the infusion except for planned lymphodepletion. Monitor blood counts and infection closely if chemotherapy is unavoidable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Other interactions of Tisagenlecleucel
Frequently asked questions
Can I take Oxaliplatin with Tisagenlecleucel?
MediHelp rates the interaction as major. Oxaliplatin and Tisagenlecleucel can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Oxaliplatin is myelosuppressive and immunosuppressive, and giving it around the time of CAR-T cell therapy may impair the expansion and persistence of the infused cells. It also adds to the infection risk from cytopenias after CAR-T therapy.
How serious is the interaction between Oxaliplatin and Tisagenlecleucel?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid chemotherapy in the period shortly before and after the infusion except for planned lymphodepletion. Monitor blood counts and infection closely if chemotherapy is unavoidable.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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