Drug interactions
Oxaliplatin + Trastuzumab
Severity: Moderate
Oxaliplatin and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Trastuzumab with myelosuppressive chemotherapy such as oxaliplatin has been associated with more neutropenia and febrile neutropenia. Infection risk may be higher as a result.
What this interaction means in plain words
Oxaliplatin and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxaliplatin belongs to Oncology; Trastuzumab belongs to Oncology.
Why it happens
Additive pharmacodynamic effect on neutrophil counts when trastuzumab is added to myelosuppressive chemotherapy.
What to do
Monitor complete blood counts and signs of infection. Use growth factor support or dose delays per protocol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaliplatin
- Adenovirus types 4 and 7 live + Oxaliplatin Contraindicated
- Bcg vaccine live + Oxaliplatin Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine live + Oxaliplatin Contraindicated
- Measles mumps and rubella vaccine + Oxaliplatin Contraindicated
- Measles mumps rubella and varicella vaccine live + Oxaliplatin Contraindicated
Other interactions of Trastuzumab
Frequently asked questions
Can I take Oxaliplatin with Trastuzumab?
MediHelp rates the interaction as moderate. Oxaliplatin and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Trastuzumab with myelosuppressive chemotherapy such as oxaliplatin has been associated with more neutropenia and febrile neutropenia. Infection risk may be higher as a result.
How serious is the interaction between Oxaliplatin and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor complete blood counts and signs of infection. Use growth factor support or dose delays per protocol.
What other medicines interact with Oxaliplatin?
MediHelp also lists interactions of Oxaliplatin with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Oxaliplatin page.
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