Drug interactions
Oxaprozin + Pralatrexate
Severity: Moderate
Oxaprozin and Pralatrexate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may reduce the renal elimination of pralatrexate, raising its exposure and the risk of toxicity such as mucositis and myelosuppression. Pralatrexate is renally cleared, so impaired renal function compounds the effect.
What this interaction means in plain words
Oxaprozin and Pralatrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxaprozin belongs to Musculoskeletal; Pralatrexate belongs to Oncology.
Why it happens
NSAIDs reduce renal blood flow and may compete for renal tubular secretion, delaying pralatrexate clearance.
What to do
Monitor for pralatrexate toxicity and renal function when an NSAID is given concurrently. Adjust pralatrexate dose per labeling or avoid the NSAID.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Pralatrexate
Frequently asked questions
Can I take Oxaprozin with Pralatrexate?
MediHelp rates the interaction as moderate. Oxaprozin and Pralatrexate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may reduce the renal elimination of pralatrexate, raising its exposure and the risk of toxicity such as mucositis and myelosuppression. Pralatrexate is renally cleared, so impaired renal function compounds the effect.
How serious is the interaction between Oxaprozin and Pralatrexate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for pralatrexate toxicity and renal function when an NSAID is given concurrently. Adjust pralatrexate dose per labeling or avoid the NSAID.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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