Drug interactions
Oxaprozin + Probenecid
Severity: Moderate
Oxaprozin and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid can raise oxaprozin plasma concentrations, increasing the risk of NSAID adverse effects. Oxaprozin may in turn interfere with the uricosuric effect of probenecid.
What this interaction means in plain words
Oxaprozin and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxaprozin belongs to Musculoskeletal; Probenecid belongs to Genitourinary.
Why it happens
Probenecid inhibits renal tubular anionic transport (OAT) and glucuronidation, reducing NSAID clearance.
What to do
Monitor for NSAID adverse effects such as GI and renal toxicity and consider reducing the oxaprozin dose. Check urate response to probenecid.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Oxaprozin and Probenecid, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Oxaprozin with Probenecid?
MediHelp rates the interaction as moderate. Oxaprozin and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid can raise oxaprozin plasma concentrations, increasing the risk of NSAID adverse effects. Oxaprozin may in turn interfere with the uricosuric effect of probenecid.
How serious is the interaction between Oxaprozin and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for NSAID adverse effects such as GI and renal toxicity and consider reducing the oxaprozin dose. Check urate response to probenecid.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
