Drug interactions
Oxaprozin + Sertraline
Severity: Moderate
Oxaprozin and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining an NSAID with an SSRI raises the risk of bleeding, particularly upper gastrointestinal bleeding. Risk is greater in older patients and those with prior ulcers or taking other antithrombotics.
What this interaction means in plain words
Oxaprozin and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxaprozin belongs to Musculoskeletal; Sertraline belongs to Central Nervous System.
Why it happens
SSRI depletion of platelet serotonin impairs aggregation, adding to NSAID platelet inhibition and mucosal injury.
What to do
Monitor for GI bleeding and consider a proton pump inhibitor in at-risk patients. Prefer a non-NSAID analgesic where possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Oxaprozin with Sertraline?
MediHelp rates the interaction as moderate. Oxaprozin and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining an NSAID with an SSRI raises the risk of bleeding, particularly upper gastrointestinal bleeding. Risk is greater in older patients and those with prior ulcers or taking other antithrombotics.
How serious is the interaction between Oxaprozin and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding and consider a proton pump inhibitor in at-risk patients. Prefer a non-NSAID analgesic where possible.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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