Drug interactions
Oxaprozin + Sparsentan
Severity: Moderate
Oxaprozin and Sparsentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan blocks endothelin and angiotensin receptors and lowers glomerular pressure; NSAIDs can further impair renal perfusion. This may worsen kidney function, particularly with volume depletion.
What this interaction means in plain words
Oxaprozin and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Oxaprozin belongs to Musculoskeletal; Sparsentan belongs to Genitourinary.
Why it happens
NSAID inhibition of renal prostaglandins combined with angiotensin receptor and endothelin blockade reduces glomerular filtration.
What to do
Monitor serum creatinine and potassium and blood pressure when an NSAID is used with sparsentan. Avoid chronic NSAID use and maintain hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Oxaprozin with Sparsentan?
MediHelp rates the interaction as moderate. Oxaprozin and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sparsentan blocks endothelin and angiotensin receptors and lowers glomerular pressure; NSAIDs can further impair renal perfusion. This may worsen kidney function, particularly with volume depletion.
How serious is the interaction between Oxaprozin and Sparsentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and potassium and blood pressure when an NSAID is used with sparsentan. Avoid chronic NSAID use and maintain hydration.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
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